Drug abuse and addiction can prove to be a significant challenge to overcome. While alcohol and caffeine are the most common substances to become addicted to, both are legal and easily accessible. As we venture into the statistics of illicit drug use, the number of those who report usage may surprise you.

Uncovering Which Drugs See the Most Use

When you decide to start using drugs, you’re deciding to alter how your mind and body function. The presence of chemicals found in various drugs will attach to different neurotransmitters in your brain when consumed. These centers for motor control, mood regulation, and dopamine all begin operating differently due to outside interference.

With that in mind, it’s easy to understand how any substance that interacts with our bodies can create an addiction. Removing the substance means withdrawal symptoms full of pain and discomfort, leading to many individuals choosing to continue using drugs instead of quitting.

2021’s Drug Abuse Statistics report shows us that marijuana is the most commonly used illicit drug in the United States. What’s even more concerning are the numbers regarding first-time marijuana users. Over 3 million Americans try cannabis for the first time every year, with legalization at the state level making it easier to obtain the substance.

A common misconception about marijuana is that since it’s natural, there’s no chance of becoming addicted. The truth is that while marijuana doesn’t develop the same physical dependencies as other drugs do, the psychological impacts can be significant. Your brain’s ability to reward you starts being run solely by marijuana, leaving you with depression and anxiety when it’s no longer available.

Less Common but More Dangerous Drugs

Marijuana

Even though marijuana isn’t a life-threatening drug, the addiction that can be formed around it can negatively impact multiple areas of your life. Unfortunately, there are other drugs still being abused with much more severe side effects both during and after use.

Alcohol

While marijuana holds the title as the most commonly used illicit drug, alcohol remains the most widely abused legal substance in the United States. Its legal status and cultural acceptance can blur the line between casual use and harmful dependency. According to the National Institute on Alcohol Abuse and Alcoholism, over 14 million adults in the U.S. live with Alcohol Use Disorder (AUD). Binge drinking — defined as consuming several drinks in a short period — is especially prevalent, particularly among young adults and college-age individuals. Despite its familiarity, alcohol addiction can quietly affect every aspect of life, from physical health to mental well-being, often going untreated until serious consequences arise.

Opioids and Opiates

Derived from the poppy plant, opioids are extremely effective pain relievers used by millions of Americans. The term opioid encompasses both natural and synthetic opioids, whereas opiate refers only to natural opioids such as heroin and morphine.

Opioid abuse quickly became an epidemic when they entered the pharmaceutical market more heavily. Doctors were told by pharmaceutical companies that opioid painkillers were non-habit forming, a deception that has led to mass drug dependence. The pain relief and feelings of euphoria that opioids provide are why so many chase the “high,” even after a legitimate prescription is provided.

Stimulants or “Uppers”

Commonly prescribed to treat attention disorders such as ADHD, stimulants like Adderall and Ritalin can improve focus and energy levels when used correctly. These medications alter the brain’s chemical balance, making it easier for individuals with ADHD to concentrate and manage impulses. However, misuse of stimulants for performance enhancement or recreational purposes has become increasingly common, especially among students and professionals. This misuse often stems from the desire to prolong productivity or experience a euphoric “rush.” Over time, the body builds a tolerance, leading to increased dosage and dangerous side effects like elevated heart rate, high blood pressure, and seizures. In severe cases, stimulant abuse can lead to heart failure or sudden death.

When abused, users are looking for a dopamine rush, which increases feelings of pleasure. The side effects are increased blood pressure and heart rate, leading to a heart attack or stroke when consumed in large quantities. Dangerous fevers, seizures, and irregular heartbeat are all common signs of severe stimulant abuse and are often precursors to a potentially life-threatening overdose.

Cocaine

Cocaine, a powerful and fast-acting stimulant, continues to pose a significant threat, particularly among younger demographics. Often used in pursuit of energy and euphoria, cocaine works by increasing dopamine levels in the brain, but at a steep cost. Short-term effects include intense bursts of energy and confidence, while long-term use is linked to heart attacks, strokes, and severe psychological distress. According to recent findings from the National Institute on Drug Abuse, over 1.5 million people in the U.S. reported using cocaine in the past year. Its addictive nature and the potential for sudden overdose make it one of the most dangerous drugs still circulating today.

Central Nervous System Depressants

It’s important to understand that depressants aren’t used to treat depression but instead depress how active your central nervous system is. They tend to be used in the treatment of anxiety, chronic panic, and sleep disorders. Sedatives, tranquilizers, and hypnotics all fall under the depressant umbrella and include drugs such as Ambien for sleep and Valium or Xanax for anxiety.

The ability of these drugs to allow a patient to sleep through the night or have a day without constant stress can’t be discounted. It’s when the situation surrounding the use of these drugs changes into a negative experience. Misuse of depressants can lead to:

  • Trouble focusing
  • Dizziness
  • Loss of memory or trouble creating new memories
  • Issues with basic movement
  • Drowsiness
  • Slurred speech
  • Confusion
  • Low blood pressure
  • Shallow breathing

Over-the-Counter Medications

Some medications found in your local pharmacy, such as cough syrups containing dextromethorphan or anti-diarrheal products with loperamide, can be misused for their psychoactive effects. While these drugs are safe when used as directed, consuming them in large quantities can mimic the effects of opioids or hallucinogens. Teenagers and young adults are particularly vulnerable, drawn in by the easy accessibility of these products. It’s a reminder that addiction can stem from even the most unassuming sources.

Breaking Away From Addiction

Addiction doesn’t always start with a clear warning sign. It can begin with a prescription, a celebration, or a moment of escape, and quickly turn into something far more consuming. At America’s Rehab Campus, we understand that every path to addiction is different, which is why our programs are designed with compassion, personalization, and evidence-based care. If you or someone you care about is struggling with substance abuse, don’t wait for rock bottom. Our confidential consultations are free, and recovery can start with a single conversation. Reach out to us today and reclaim control of your life.

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Dr. Paul R. Valbuena, M.D. Chief Medical Officer
Paul R. Valbuena, M.D., is a double-board-certified psychiatrist practicing in the Phoenix Metro area since 2009. Licensed in Arizona, he specializes in behavioral health, child and adolescent psychiatry, and addiction psychiatry. A diplomate of the American Board of Psychiatry and Neurology, Dr. Valbuena has been a practicing physician since 2003.